The group of Animal Physiology, Institute of Agricultural Science at ETH Zurich, addresses the complex regulation of health and performance in livestock. Reproductive challenges are addressed and include an epigenetic perspective on embryo development. The Reproductive Cell Biology Unit at the Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Germany, adopts in vitro models to understand the highly dynamic cellular molecular mechanisms underlying embryo-maternal interactions. Starting from March 1st, 2018 we offer a
PhD Position in Epigenetics and Reproduction
Using 3D-Air-Liquid-Interface cultures of porcine endometrial epithelia (3D-ALI-PEEC) to decipher embryo-maternal-interactions that deteriorate embryo development after exposition to endocrine disrupting chemicals. The periconceptual phase of embryo development is most vulnerable to environmental influences that can impact on health and disease of the individual and further generations. Understanding the epigenetic mechanisms underlying these long-term programming effects is of importance to effectively prevent issues of affluence such as diabetes, obesity and infertility. The research study funded by the SNF (Swiss National Science Foundation) comprises effects of endocrine disrupting chemicals on the developing embryo in vivo and in vitro. The PhD candidate will be involved in conducting a large animal model study and specifically focus in vitro on 3D-Air-Liquid-Interface cell cultures. Analyses of epigenetic modifications, including cell-specific DNA methylome sequencing will be undertaken to elucidate the molecular mechanisms by which estrogens exert an impact on embryonic development.
We are looking for an early experienced, highly motivated young researcher with a strong enthusiasm for scientific work to contribute to our interdisciplinary research group. Applicants have completed a master degree in biochemistry, biology, molecular biotechnology, agricultural sciences or related disciplines. Profound experience with techniques of molecular biology and epigenetics is required. Candidates have the ability to work independently in an interdisciplinary research environment. Very good knowledge of spoken and written English is essential.

We offer a very well equipped facility at ETH Zurich in a workplace of a young and emerging research group will be available. Collaboration within the interdisciplinary Animal Physiology group and outside are anticipated. Particularly, the 3D-cell culture experiments will be undertaken during a 1-year stay with Dr. Jennifer Schön at the Reproductive Cell Biology Unit, FBN, Dummerstorf, Germany. Publication activities and conference participations are promoted.
We look Forward to receiving your online application including a letter of motivation and a detailed CV with copies of certificates to Prof. Ulbrich. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. The selection process will be continued until the position is filled.

For further information related to the position or the Doctorate at ETH Zurich please contact Prof. Ulbrich via email (sulbrich[at]ethz.ch) and/or visit our website www.ap.ethz.ch.