As a leading international academic institution at the cutting edge of health sciences and technology, the aim of the Department of Health Sciences and Technology (D-HEST) is to create the foundations for sustaining and improving the quality of life for people into old age. The Department of Health Sciences and Technology will accelerate the transfer of knowledge and technology in clinics, industry and society, and educate a new generation of students at the interface of science and technology. The Laboratory of Applied Mechanobiology is positioned on the interface of state-of-the-art microscopy and and nanomedicine with the focus on immunology.
2 Ph.D. candidates in biophysics, super-resolution microscopy and gene expression during T-cell activation
We are looking for outstanding, highly motivated individuals interested in pursuing Ph.D. research in the multi-disciplinary and challenging area of state-of-the-art single molecule microscopy techniques such as super-resolution microscopy, AFM and optical tweezer to gain insights into general aspects of mechanobiology, T-cell activation, gene expression and immunology. Gene regulation for T-cell activation happens on a very fast timescale as the immune response is critical for the body´s defense mechanism. The chromatins’ three-dimensional organization in T-cells as well as its interaction with nuclear lamina and the consequential impact on gene regulation is poorly understood. Our research focusses on how mechanical forces can directly influence cellular functions, such as the T-cell activation, and furthermore elucidate how they ultimately change gene expression. The mechanical force triggers structural/conformational changes of the nuclear lamina network; hence, genes encoded in chromatin proximal to lamina can be up/down regulated. For verifying the new concepts and the models, a Lattice Light Sheet microscope will be built and evaluated in detail. You may expect a challenging and scientifically highly exciting position in a dynamic, international team at one of the world-wide leading technical universities. Furthermore, we strongly support participation at international conferences and offer a competitive salary, excellent benefits as well as outstanding research and laboratory facilities.
The candidate must have a diploma/M.Sc. degree in biomedical engineering, cell biology and/or physics with excellent grades, fundamental knowledge of cell biology and biophysics, good communication skills, fluency in English and the willingness to work hard as part of an international team. In addition, you should be interested in super-resolution microscopy, immunobiology and gene expression.
We look forward to receiving your application inculding a letter of motivation, CV, B.S. and M.S. transcripts, electronic copies of the B.Sc./M.Sc. thesis and/or publications (if available) and names and addresses of references. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

For further information please visit our website http://www.appliedmechanobio.ethz.ch/the-laboratory/people/scientific-assistants/Enrico.html or contact Dr. Enrico Klotzsch at enrico.klotzsch[at]hest.ethz.ch (no applications).