The research group of Dr. Alexander Leitner at the Institute of Molecular Systems Biology at ETH Zurich ( offers a position for a
Postdoctoral Researcher, Structural Mass Spectrometry / Proteomics
The group headed by Dr. Leitner is embedded within the laboratory of Prof. Ruedi Aebersold and focuses on the development of mass spectrometry-based structural proteomics applications, in particular cross-linking strategies, and their applications in structural and systems biology.

The research project is part of the framework “Strategic Focus Area Personalized Health and Related Technologies (PHRT)” of the ETH domain ( and connected to the national Swiss Personal Health Network ( The PHRT program has been established to develop applications of life science and data science technology developed at ETH research institutions towards biomedical research. This includes applications such as disease diagnostics and biomarker discovery for new and improved treatment options targeted at individual patients or patient subgroups.

Within this context, the present project aims at using protein-RNA interaction signatures for elucidating mechanisms in neurodegenerative and myodegenerative diseases. For this purpose, CLIR-MS, a photochemical cross-linking strategy in combination with mass spectrometry analysis will be used, as reported recently (Dorn et al., Nat. Methods 2017). The project is carried out in collaboration with the laboratory of Prof. Frédéric Allain (, with whom we developed CLIR-MS, and external partners at the University of Zurich and the University Hospital Zurich. The position is funded for two years with a salary in accordance with ETH rates, and is available from March 2018 or upon negotiation.

We are looking for candidates with a solid background in mass spectrometry-based proteomics, ideally with experience in structural applications of MS. Alternatively, applications from researchers with a background in RNA and/or structural biology with a strong interest in learning and applying mass spectrometry in their research will be considered. Ideal complementary skills include experience in working with patient-derived clinical material (tissue) and/or programming/scripting. Interest in working in a multidisciplinary project with a focus on clinical applications is essential, as is fluency in English, the working language of the lab. German language skills are not required.
We look forward to receiving your online application including a letter of motivation (specifying a possible starting date), CV/publications list, diplomas and contact details of two references. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. Applications received until February 11 will be considered.

For further information please visit our Website and for questions regarding the position please contact Dr. Alexander Leitner by e-mail (Leitner[at]