The Institute of Molecular Systems Biology (IMSB) is in the Department of Biology at the ETH Zurich. The research groups at IMSB share the same mission: we all work to develop, apply and teach the science of Systems Biology. The laboratory of Dr. Nicola Zamboni invites applications for a
PhD position in systems biology of lymphatic cells
The research group at Campus ETH Hönggerberg investigates cellular metabolism, and is particularly attracted by problems of biomedical relevance and are difficult to address because complex or technically challenging. To tackle such problems, the lab resorts to a large portfolio of methods including cutting-edge mass spectrometry (i.e. metabolomics and 13C flux analysis) and computational biology. The group has a long standing experience in developing such methods and applying them to a broad range of biological systems and questions.

We are looking for a candidate who is highly motivated to perform in-depth metabolic characterization of lymphatic endothelial cells and of samples from patients with lymphatic disorders. Lymphatic vasculature is the least studied arm of cardiovascular system, indispensable for maintenance of plasma and tissue volume, body immunosurveillance, as well as absorption of lipid species. To fill this gap, we are teaming up with experts on the topic with access to powerful murine models and patient material. Our task is to investigate how metabolism of isolated cells and lymphatic systems of animal models and humans respond to genetic and environmental perturbations.
The ideal candidate will be on charge of the metabolic characterization of cells and patient samples. These experiments will include metabolomics, physiological assays, 13C metabolic flux analysis, and RNAseq. The candidate is expected to getting acquainted with state-of-the-art techniques, exploit them to explore largely uncharted terrain at the interface of biochemistry, cell biology, and lymphatic disorders. Candidates with experience in metabolism and/or cell biology will be preferred. We value passion about biomedical research and critical thinking. The student will be embedded in the Zurich Life Science Graduate School and further profit from the courses and network offered by the program.
We look forward to receiving your online application including a letter of motivation, CV, transcripts and contact details of 2 referees. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

For further information about the institute please visit our website www.imsb.ethz.ch.