The Institute of Molecular Systems Biology (IMSB) is in the Department of Biology at the ETH Zurich. The research groups at IMSB share the same mission: we all work to develop, apply and teach the science of Systems Biology. The laboratory of Dr. Nicola Zamboni invites applications for a
PhD position in metabolic engineering
The research group at Campus ETH Hönggerberg investigates cellular metabolism, and is particularly attracted by problems of biomedical relevance and are difficult to address because complex or technically challenging. To tackle such problems, the lab resorts to a large portfolio of methods including cutting-edge mass spectrometry (i.e. metabolomics and 13C flux analysis) and computational biology. The group has a long standing experience in developing such methods and applying them to a broad range of biological systems and questions.

We are looking for a candidate who is highly motivated to develop and demonstrate the application of metabolomics in metabolic engineering, i.e. the optimization of cells for the commercial production of valuable compounds. For instance, metabolomics can support rational strain optimization e.g. by enabling (i) metabolic flux analysis, (ii) the elucidation of pathway regulation, or (iii) unraveling metabolic limitations in the host. Further, high-throughput metabolomics is ideally suited to screen mutant libraries with tens of thousands of strains. The project aims at synergistically integrating modern tools of synthetic and systems biology for the efficient optimization of microbial cell factories.
The ideal candidate has a solid background in quantitative bioengineering. She/he will be responsible for the in-depth metabolic characterization of strains using metabolomics, 13C metabolic flux analysis, and dynamic modeling. The project is a collaboration with a lab expert in synthetic biology. The candidate is expected to act as the main interface with external partners. This demands an outgoing personality and strong communication skills. Most importantly, the candidate must be passionate about research and innovation. The student will be embedded in the Zurich Life Science Graduate School and further profit from the courses and network offered by the program.
We look forward to receiving your online application including a letter of motivation, CV, transcripts and contact details of 2 referees. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

For further information about the institute please visit our website www.imsb.ethz.ch.