Eawag, the Swiss Federal Institute of Aquatic Science and Technology, is an internationally networked aquatic research institute within the ETH Domain (Swiss Federal Institutes of Technology). Eawag conducts research, education and expert consulting to achieve the dual goals of meeting direct human needs for water and maintaining the function and integrity of aquatic ecosystems.
Traditionally, fish toxicity data required for environmental risk assessment have been obtained from chronic toxicity tests with juvenile or adult fish. These tests are, however, lengthy, costly and ethically challenged due to high animal use. We at Utox therefore work to develop alternative (non-animal) assessment methods that could reduce the need for animal testing. One approach we are using seeks to predict chemical-induced organism-level effects in vivo based on molecular and cellular changes measured in vitro.
The specific postdoc project advertised here focuses on the mechanistic target of rapamycin (mTOR) pathway and its potential role in mediating chemical effects on growth in fish. Its goals are to characterize the basal functionality of this pathway in fish cells cultured in vitro and to investigate the consequences of the mTOR signalling disruption by physiological or chemical stressors for metabolic status, growth and proliferation of cells. A crucial project task entails the establishment of mass spectrometry-based targeted assays to measure protein phosphorylation dynamics along the mTOR pathway, as a means to circumvent the existing methodological challenges resulting from the lack of species-specific antibodies for (de)phosphorylated proteins of interest.
Candidates for this position should hold a PhD in proteomics, bioanalytics, biochemistry, molecular biology or similar areas, and possess a solid hands-on experience in mass spectrometry analysis and data interpretation. Experience with cell cultures or other (alternative) toxicological test models in the context of environmental risk assessment will be a plus. Candidates should convince by a strong record of academic achievements, solid work ethics, mature teamwork attitude, and well-developed communication skills in English. The ability to work independently and eagerness to demonstrate self-initiative in approaching research questions and challenges are also essential. Last but not least, we look for individuals who share our passion for science and are keen to make a meaningful contribution to the advancement of our research field.
The Department of Environmental Toxicology offers a stimulating research atmosphere, excellent opportunities for collaborative work and multiple possibilities for further education and training to support professional development goals of its employees. Our in-house research infrastructure includes well-equipped cell culture and fish culture facilities along with molecular biology laboratories and a state-of-the-art mass spectrometry facility.
a modern employer and offers an excellent working environment where staff can contribute their strengths, experience and ways of thinking. We promote gender equality and are committed to staff diversity and inclusion. The compatibility of career and family is of central importance to us. For more information about Eawag and our work conditions, please consult www.eawag.ch
Applications will be accepted until 29 August 2021, and should include a cover letter clearly explaining your research background and motivation to apply for this position, a CV and list of publications, copies of your academic qualifications and contact information for two references. Letters of support can also be included. The preferred start date is 1 October 2021, or as soon as possible thereafter. The position is initially funded for two years.
We look forward to receiving your application. Please send it through this webpage, any other way of applying will not be considered. A click on the button below will take you directly to the application form.
Applications from employment agencies/personnel consultants are not welcome and will not be considered.