Eawag, the Swiss Federal Institute of Aquatic Science and Technology, is an internationally networked aquatic research institute within the ETH Domain (Swiss Federal Institutes of Technology). Eawag conducts research, education and expert consulting to achieve the dual goals of meeting direct human needs for water and maintaining the function and integrity of aquatic ecosystems.
Did you know that, to this day, environmental risk assessment relies to a large extent on long-term toxicity tests with fish? These tests are lengthy, costly, and ethically challenged. We at Utox work to develop alternative (non-animal) methods to reduce the need for animal testing. One our strategy seeks to predict chemical-induced organism-level effects in vivo based on molecular or cellular changes measured in vitro.
This postdoc project will focus on the role of the mechanistic target of rapamycin (mTOR) pathway in mediating chemical effects on growth in fish. In vitro cultured fish cells will be used as a model to study the consequences of the mTOR signalling disruption for cell metabolic status, growth and proliferation. Protein phosphorylation dynamics along the mTOR pathway will be monitored by means of mass spectrometry-based targeted proteomics assays to understand their causal relationships with the cell outcomes.
We are looking for candidates who share our passion for finding alternatives to animal testing and are keen to make a meaningful contribution to the advancement of mechanistic toxicology. You should hold a PhD in environmental or biological sciences, with a background in proteomics, bioanalytics, biochemistry, molecular biology, cell biology or similar areas. Hands-on experience in mass spectrometry analysis and/or data interpretation is crucial. Experience in cell culture and/or toxicological testing will be an asset. Solid work ethics, mature teamwork attitude and good communication skills in English are also essential.
a modern employer and offers an excellent working environment where staff can contribute their strengths, experience and ways of thinking. We promote gender equality and are committed to staff diversity and inclusion. The compatibility of career and family is of central importance to us. For more information about Eawag and our work conditions, please consult www.eawag.ch
Deadline for applications is 12 November 2021 or until the position is filled (applications will be screened continuously). Your application should include a cover letter explaining your research background and motivation to apply for this position, a CV with list of publications, copies of your academic qualifications and contact information for two references. The appointment period for this position is 24 months and the starting date is as soon as possible upon agreement.
We look forward to receiving your application. Please send it through this webpage, as any other way of applying will not be considered. A click on the button below will take you directly to the application form.